Custom Peptides
Cayman Chemical NMS-1286937 10mg
An inhibitor of Plk1 (IC50 = 2 nM); selective for Plk1 over Plk2 and Plk3 (IC50s = >10,000 nM for both); inhibits proliferation of A2780 cells (IC50 = 42 nM); halts the cell cycle at the G2/M phase in A2780 cells at 20-200 nmol/L and induces apoptosis; reduces tumor growth in an HCT116 mouse xenograft model at 60 mg/kg once per day; induces tumor regression in an HT-29 mouse xenograft model at 45 mg/kg in combination with CPT11
Chem-Impex International, Inc. FMOC GLY THR PSI MEME PRO OH1G
NC3761731 FMOC GLY THR PSI MEME PRO OH1G
Cayman Chemical nglada oxbugna ngltn 10mg
A flavonoid glycoside; scavenges ABTS radicals in a cell-free assay (IC50 = 18.13 UG/ml); induces apoptosis in MCF-7 and MDA-MB-231 human breast cancer cells at 2 UG/ml; inhibits LPS-induced production of IL-1β, IL-6, and NO in isolated rat chondrocytes, as well as reduces cartilage erosion and the loss of proteoglycan in the inflamed joints in a rat model of surgically induced osteoarthritis
Cayman Chemical B-HT 933hydrochlorIde 10mg
An α2-AR agonist (EC50 = 0.65 μM for contraction of canine sapheneous veins); induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum; induces sedation and reduces motor activity in mice, an effect that is reversed by the α2-AR antagonist yohimbine; decreases blood pressure and cardiac output in cats injected with 30 μg/kg intracisternally; exhibits antinociceptive effects in mice (ED50s = 12.5, 20.5, and 6.1 mg/kg for the tail-immersion, tail-pinch, and acetic acid writhing tests, respectively)
Cayman Chemical 5-trns ProstaglndIn D2 10mg
The trans isomer of PGD2 occurs as an impurity between 2-5% in most commercial preparations of the bulk drug product. This compound was prepared primarily as an analytical standard for detection and quantitation of this impurity. From what can be inferred from the study of other trans isomers of F-type prostaglandins, the biological activity of 5-trans PGD2 is likely to be similar to that of the cis isomer. However, there are no specific published reports on the biological activity of 5-trans PGD2.
Cayman Chemical 2 3 5trIacetyl5AzacytId 10mg
A prodrug form of 5-azacytidine; decreases promoter methylation of P15 in L1210 mouse leukemia cells at 1 and 100 µM; reduces HIV-1 infection in, and increases the viability of, unstimulated primary human CD4+ T cells at 10 µM; decreases gut and spleen global DNA methylation levels in mice at 38 mg/kg per day for 5 consecutive days
Cayman Chemical HexahydrocurcumIn 10mg
A natural product and an active metabolite of curcumin; has anti-inflammatory, antioxidant, and anticancer properties; reduces PMA-induced PGE2 production by 37% in human colonic epithelial cells (20 µM); inhibits LPS-induced overproduction of nitric oxide in RAW 264.7 macrophage cells (3.125-25 µM); inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation (50 µM); prevents formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer
Cayman Chemical NpentadecnoylLHomoserIn 10mg
A bacterial quorum-sensing signaling molecule; activates the LasR quorum sensing receptor of bacteria in a reporter assay; induces GFP production in a P. putida F117 reporter strain expressing the pKR-C12 quorum-sensing operon at 0.094 nM
Cayman Chemical Betulonaldehyde 10mg
A pentacyclic triterpenoid; active against P. falciparum (IC50 = 3.36 UG/ml); cytotoxic to NCI H187 and Vero cells (IC50s = 19.23 and 17.09 UG/ml, respectively); reduces TPA-induced EAr edema in mice at 1 mg/ear; has also been used a precursor in the semisynthesis of C-2 and C-28 betulonic aldehyde derivatives
Cayman Chemical MEGXhydrochlorIde 10mg
An active metabolite of lidocaine; formed via N-deethylation of lidocaine by hepatic CYP3A4; topical administration reduces thrombus formation in a hamster model of laser-induced microvascular injury at 2% v/v; plasma levels following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis
Cayman Chemical PImecrolImus 10mg
A macrolactam that binds to macrophilin-12 and inhibits calcineurin as well as prolyl isomerase; the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) and suppresses the generation of pro-inflammatory cytokines; used in countering inflammatory skin diseases, such as eczema and psoriasis
Cayman Chemical VU6036720hydrochlorIde 10mg
An inhibitor of heteromeric Kir4.1/5.1 channels (IC50 = 0.24 µM); selective for Kir4.1/5.1 channels over a variety of homomeric Kir channels, including Kir4.1 (IC50 = >10 µM), as well as heteromeric Kir3.1/3.2, Kir3.1/3.4, Kir6.2/SUR1, and Kir6.1/SUR2b channels at 30 µM but does inhibit the voltage-gated potassium channel Kv1.1 (IC50 = 6.4 µM); does not inhibit diuresis in mice at 30 and 100 mg/kg due to low oral bioavailability and high hepatic clearance
Cayman Chemical DImethocaInhydrochlorIde 10mg
A local anesthetic that, because of its similarity in action to cocaine, has potential for abuse; completely inhibits dopamine uptake in rat striatal synaptosomes with an IC50 value (1.2 µM) comparable to that of cocaine (IC50 = 0.7 µM); substitutes for cocaine in drug discrimination tests in rats and rhesus monkeys; intended for forensic and research purposes
Cayman Chemical 2 3DImethylethcathInonhyd 10mg
A disubstituted analog of ethcathinone; intended for forensic and research purposes
Cayman Chemical 4-APBhydrochlorIde 10mg
An analytical reference standard categorized as a benzofuran; a potential metabolite of 4-MAPB and 4-EAPB based on the published metabolism of 5-MAPB; intended for research and forensic applications